Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor

• Published in: Angewandte Chemie International Edition Vol. 51; no. 16; pp. 3897 - 3900
• Main Authors: Betanzos-Lara, Soledad, Liu, Zhe, Habtemariam, Abraha, Pizarro, Ana M., Qamar, Bushra, Sadler, Peter J.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 16.04.2012; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: arenes; bio-organometallics; Catalysis; Catalysts; Cell Line, Tumor; Coordination Complexes - chemistry; Derivatives; Humans; hydride transfer; Hydrides; Hydrogenation; Iridium; Iridium - chemistry; Ketones; Ketones - chemistry; Ligands; Metalorganic compounds; NAD - chemistry; NADH; Oxidation-Reduction; Ruthenium; Ruthenium - chemistry; Water - chemistry

Artificial enzymes: Half‐sandwich arene ruthenium(II) and cyclopentadienyl iridium(III) complexes containing N,N‐chelated ligands can use NADH as a source of hydride for the reduction of ketones (see picture). Moreover, cyclopentadienyl phenanthroline iridium(III) derivatives at micromolar concentra...