Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor

Artificial enzymes: Half‐sandwich arene ruthenium(II) and cyclopentadienyl iridium(III) complexes containing N,N‐chelated ligands can use NADH as a source of hydride for the reduction of ketones (see picture). Moreover, cyclopentadienyl phenanthroline iridium(III) derivatives at micromolar concentra...

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Published inAngewandte Chemie International Edition Vol. 51; no. 16; pp. 3897 - 3900
Main Authors Betanzos-Lara, Soledad, Liu, Zhe, Habtemariam, Abraha, Pizarro, Ana M., Qamar, Bushra, Sadler, Peter J.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.04.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
arenes
bio-organometallics
Catalysis
Catalysts
Cell Line, Tumor
Coordination Complexes - chemistry
Derivatives
Humans
hydride transfer
Hydrides
Hydrogenation
Iridium
Iridium - chemistry
Ketones
Ketones - chemistry
Ligands
Metalorganic compounds
NAD - chemistry
NADH
Oxidation-Reduction
Ruthenium
Ruthenium - chemistry
Water - chemistry
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Summary:Artificial enzymes: Half‐sandwich arene ruthenium(II) and cyclopentadienyl iridium(III) complexes containing N,N‐chelated ligands can use NADH as a source of hydride for the reduction of ketones (see picture). Moreover, cyclopentadienyl phenanthroline iridium(III) derivatives at micromolar concentrations are robust catalysts for the production of H2 from NADH in water and can raise the NAD+/NADH ratio in cancer cells.
Bibliography:WPRS
CONACyT Mexico
ArticleID:ANIE201108175
We thank the WPRS and the ORSAS (S.B.-L. and Z.L.), and the CONACyT Mexico (S.B-L.) for research scholarships, the EPSRC, the ERC (BIOINCMED), the ERDF, and the AWM (Science City) for funding. Dr. Ivan Prokes, Dr. Lijiang Song, and Mr Philip Aston (University of Warwick) are acknowledged for assistance with the NMR and MS instruments, respectively, Prof. Colin Murrell and Dr. Andrew Crombie are thanked for assistance with the gas chromatograph, and Dr. Ying Fu and Dr. Maria Romero Castro are thanked for helpful discussions.
ERC
AWM
EPSRC
ark:/67375/WNG-KNK2N159-R
ORSAS
ERDF
istex:E0A09C6928D77CD1FD806A80D883BB4153646BA0
The first two authors are equal first authors.
We thank the WPRS and the ORSAS (S.B.‐L. and Z.L.), and the CONACyT Mexico (S.B‐L.) for research scholarships, the EPSRC, the ERC (BIOINCMED), the ERDF, and the AWM (Science City) for funding. Dr. Ivan Prokes, Dr. Lijiang Song, and Mr Philip Aston (University of Warwick) are acknowledged for assistance with the NMR and MS instruments, respectively, Prof. Colin Murrell and Dr. Andrew Crombie are thanked for assistance with the gas chromatograph, and Dr. Ying Fu and Dr. Maria Romero Castro are thanked for helpful discussions.
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SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201108175