Assessment of chamber angle pigmentation during longterm latanoprost treatment for open‐angle glaucoma

• Published in: Acta Ophthalmologica Scandinavica Vol. 82; no. 2; pp. 158 - 160
• Main Authors: Nakamura, Yuko, Nakamura, Yoshimi, Morine‐Shinjo, Sayo, Sakai, Hiroshi, Sawaguchi, Shoichi
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden , USA Wiley 01.04.2004; Blackwell Science Ltd/Inc
• Subjects: Antihypertensive Agents; Antihypertensive Agents - adverse effects; chamber angle pigmentation; Glaucoma, Open-Angle; Glaucoma, Open-Angle - drug therapy; Gonioscopy; Humans; Hyperpigmentation; Hyperpigmentation - chemically induced; Intraocular Pressure; Intraocular Pressure - drug effects; Iris Diseases; Iris Diseases - chemically induced; Latanoprost; Middle Aged; Ocular Hypertension; Ocular Hypertension - drug therapy; open‐angle glaucoma; Photography; Prostaglandins F, Synthetic; Prostaglandins F, Synthetic - adverse effects; Trabecular Meshwork; Trabecular Meshwork - drug effects
• ISSN: 1395-3907; 1600-0420
• DOI: 10.1111/j.1600-0420.2004.00243.x

. Purpose:  This study aimed to determine whether the longterm use of latanoprost is associated with an increase in trabecular pigmentation, especially in subjects in whom iris pigmentation has increased. Methods:  We enrolled 50 subjects for whom treatment was to start for ocular hypertension, primary open‐angle glaucoma or normal tension glaucoma. All subjects received latanoprost 0.005% daily. Trabecular pigmentation was documented using gonioscopic photography of the inferior quadrant at baseline, every 3 months for the first year and every 6 months for the second and third years. Three glaucoma specialists evaluated the series of gonioscopic photographs for each eye of each subject in a masked fashion. The intraocular pressure (IOP) was also recorded at each visit. Results:  A total of 41 subjects (79 eyes) completed 3 years of follow‐up, and none showed any increase in the grade of trabecular pigmentation, including 10 subjects (20 eyes) in whom the iridial pigment increased. Conclusion:  Although latanoprost increased iridial pigmentation in some subjects, we found no evidence of an increase in trabecular pigmentation over the 3 years of follow‐up.