Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults

• Published in: British journal of dermatology (1951) Vol. 181; no. 3; pp. 554 - 565
• Main Authors: Silverberg, J.I., Gelfand, J.M., Margolis, D.J., Boguniewicz, M., Fonacier, L., Grayson, M.H., Ong, P.Y., Chiesa Fuxench, Z.C., Simpson, E.L.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2019; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anxiety; Anxiety - diagnosis; Anxiety - epidemiology; Anxiety - etiology; Anxiety - psychology; Atopic dermatitis; Cross-Sectional Studies; Depression - diagnosis; Depression - epidemiology; Depression - etiology; Depression - psychology; Dermatitis; Dermatitis, Atopic - complications; Dermatitis, Atopic - diagnosis; Dermatitis, Atopic - psychology; Diagnosis; Eczema; Female; General Dermatology; Humans; Male; Medical diagnosis; Mental depression; Middle Aged; Original; Patients; Population studies; Prevalence; Psychiatric Status Rating Scales - statistics & numerical data; Quality of Life; Regression analysis; Self Report - statistics & numerical data; Severity of Illness Index; Sleep; United States - epidemiology; Young Adult; United States; United States > US
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1111/bjd.17683

Summary Background The relationship between atopic dermatitis (AD), anxiety and depression in the U.S. adult population is not well established. Objectives To determine the relationship of AD and its severity with symptoms and diagnosis of anxiety and depression in U.S. adults. Methods A cross‐sectional, population‐based study of 2893 adults was performed. AD was determined using modified U.K. Diagnostic Criteria. Results Adults with AD vs. those without AD had higher mean Hospital Anxiety and Depression Scale anxiety (HADS‐A) (7·7 vs. 5·6) and depression (HADS‐D) (6·0 vs. 4·3) scores and higher prevalences of abnormal (≥ 11) HADS‐A (28·6% vs. 15·5%) and HADS‐D (13·5% vs. 9·0%) scores. In multivariable linear and logistic regression models controlling for sociodemographics, AD was associated with significantly higher mean HADS‐A and HADS‐D scores (7·7 and 6·0) and higher odds of abnormal HADS‐A [odds ratio (OR) 2·19, 95% confidence interval (CI) 1·65–2·91] and HADS‐D scores (OR 1·50, 95% CI 1·04–2·17) (P ≤ 0·03 for all). Mean and abnormal HADS‐A and HADS‐D scores were increased in moderate and severe/very severe self‐reported global AD severity, Patient‐Oriented Eczema Measure (POEM), Patient‐Oriented Scoring AD (PO‐SCORAD), PO‐SCORAD itch and sleep (P < 0·0001 for all). All respondents with severe PO‐SCORAD, POEM and PO‐SCORAD itch had borderline or abnormal HADS‐A and HADS‐D scores. Adults with AD vs. those without AD had higher prevalence of self‐reported healthcare‐diagnosed anxiety or depression in the past year (40·0% vs. 17·5%). Many adults with AD who had borderline and/or abnormal HADS‐A or HADS‐D scores reported no diagnosis of anxiety or depression. Conclusions AD is associated with significantly increased anxiety and depression, which may go undiagnosed. What's already known about this topic? Previous studies found higher rates of anxiety and depression in clinical cohorts of patients with atopic dermatitis. What does this study add? This study found dramatically higher rates of anxiety and depression among adults with atopic dermatitis in the U.S. population, which was primarily driven by atopic dermatitis severity. Anxiety and depression often go undiagnosed in adults with atopic dermatitis. Linked Comment: Nicholas and Drucker. Br J Dermatol 2019; 181:442–443. Plain language summary available online Respond to this article