Primary non-Hodgkin’s lymphoma of the main hepatic duct junction

• Published in: Journal of Hepato‐Biliary‐Pancreatic Surgery Vol. 15; no. 4; pp. 440 - 443
• Main Authors: Shito, Masaya, Kakefuda, Toshihiro, Omori, Tai, Ishii, Seiichiro, Sugiura, Hitoshi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2008
• Subjects: Abdominal Surgery; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bile Duct Neoplasms - diagnosis; Bile Duct Neoplasms - drug therapy; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - surgery; Case Report of Interest; cholangiocarcinoma; Cholangiopancreatography, Magnetic Resonance; CHOP; Combined Modality Therapy; Gastroenterology; Hepatic Duct, Common; Hepatology; Humans; Immunohistochemistry; Lymphoma, B-Cell, Marginal Zone - diagnosis; Lymphoma, B-Cell, Marginal Zone - drug therapy; Lymphoma, B-Cell, Marginal Zone - pathology; Lymphoma, B-Cell, Marginal Zone - surgery; Male; MALT lymphoma; Medicine; Medicine & Public Health; non‐Hodgkin's lymphoma; Surgical Oncology; the main hepatic duct junction; Non-Hodgkin’s lymphoma; CHOP; MALT lymphoma; The main hepatic duct junction; Cholangiocarcinoma
• ISSN: 0944-1166; 1436-0691; 1868-6982
• DOI: 10.1007/s00534-007-1229-2

A rare case of primary non-Hodgkin’s lymphoma of the main hepatic duct junction is reported. A 71-year-old man was admitted for treatment of obstructive jaundice. Radiological examination revealed stenosis of the main hepatic duct junction. Biliary drainage was not necessary because total bilirubin decreased spontaneously. A left hepatic and caudate lobectomy, combined with resection of bile ducts and lymph node dissection, was performed with the preoperative diagnosis of cholangiocarcinoma of the main hepatic duct junction. Macroscopic examination of the resected specimen revealed tumorous growth in the main hepatic duct junction. Histological and immunochemistry findings disclosed a mucosaassociated lymphoid tissue (MALT) lymphoma. The patient received three courses of combination chemotherapy [cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP)], and there was no evidence of recurrence 45 months after the surgery. Although primary non-Hodgkin’s lymphoma of the main hepatic duct junction is extremely rare and difficult to diagnose preoperatively, aggressive surgery followed by chemotherapy, as here, is a possible curative option.