The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population

• Published in: Brain and behavior Vol. 10; no. 2; pp. e01503 - n/a
• Main Authors: Yang, Wei, Ma, Fenghui, Wang, Li, He, Xue, Zhang, Hengxun, Zheng, Jianwen, Wang, Yuhe, Jin, Tianbo, Yuan, Dongya, He, Yongjun
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2020; John Wiley and Sons Inc; Wiley
• Subjects: Age; Case-Control Studies; China - epidemiology; CYP24A1; Deoxyribonucleic acid; Disease; DNA; Female; Gender; genetic polymorphisms; Genetic Predisposition to Disease; Genotype & phenotype; Hospitals; Humans; Hypertension; Hypertension - epidemiology; ischemic stroke; Ischemic Stroke - diagnosis; Ischemic Stroke - ethnology; Ischemic Stroke - genetics; Male; Males; Middle Aged; Original Research; Polymorphism; Polymorphism, Single Nucleotide; Regression analysis; Risk Assessment; Sex Factors; Software; Stroke; Studies; Vitamin D3 24-Hydroxylase - genetics; Vitamin deficiency; China; genetic polymorphisms; ischemic stroke; CYP24A1
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1503

Aims Stroke is a complicated neurological disease and the second leading cause of death in the world. We aimed to investigate the association between CYP24A1 genetic polymorphisms and ischemic stroke risk. Methods In this case–control study, four single‐nucleotide polymorphisms of CYP24A1 were selected and genotyped by MassARRAY platform in Chinese Han population. Odds ratios and 95% confidence intervals were calculated via logistic regression analysis with adjustment in genetic models. Results Our results indicated that CYP24A1 variant (rs1570669) was associated with the decreased risk of ischemic stroke (OR = 0.60, p < .001). Stratification analysis showed that the rs6068816 could enhance the ischemic stroke risk by 1.64 times (OR = 1.64, p = .028), while rs1570669 played protective role (OR = 0.63, p = .044) in age >64 years. The rs2762934 had an increased ischemic stroke susceptibility (OR = 1.62, p = .033); however, rs1570669 might reduce stroke risk (OR = 0.61, p = .015) in age ≤64 years. The rs1570669 depressed ischemic stroke susceptibility both in female and male patients (OR = 0.46, p = .002; OR = 0.69, p = .033, respectively), and rs2296241 would weaken the risk in male (OR = 0.63, p = .012). The rs1570669 was associated with decreased risk of ischemic stroke with hypertension (OR = 0.56, p = .042). Conclusion Our study gave the evidences that CYP24A1 genetic polymorphisms were significantly associated with ischemic stroke patients, which would provide useful information of assessment or possible diagnostic markers for ischemic stroke. The results indicated that CYP24A1 rs1570669 was significantly association with stroke risk. Stratification analysis found that rs6068816 could enhance the stroke risk by 1.64 times at age >64 years, and rs2762934 had an increased stroke susceptibility in age ≤64 years. We observed that CYP24A1 rs2296241was associated with the increased stroke risk in males than in females.