Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis

Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype a...

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Bibliographic Details
Published inFEBS letters Vol. 585; no. 23; pp. 3603 - 3610
Main Authors Chavele, Konstantia-Maria, Ehrenstein, Michael R.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.12.2011
Subjects
animal models
Animals
Arthritis, Rheumatoid - immunology
Autoimmunity
Disease Models, Animal
Humans
inflammation
lupus erythematosus
Lupus Erythematosus, Systemic - immunology
Models, Immunological
pathogenesis
patients
phenotype
Regulatory T-cells (Tregs)
rheumatoid arthritis
SLE
T-lymphocytes
T-Lymphocytes, Regulatory - immunology
Autoimmunity
Regulatory T-cells (Tregs)
SLE
RA
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Summary:Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA.
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ISSN:0014-5793
1873-3468
1873-3468
DOI:10.1016/j.febslet.2011.07.043