Two-Stage Stepwise Estimation Procedure

This article proposes a two-stage simultaneous confidence procedure for the comparisons of k pairs of population means, without using multiplicity adjustment of more than two populations. The proposed procedure can be broadly applied to parametric or nonparametric models. It is robust and versatile...

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Bibliographic Details
Published inBiometrics Vol. 64; no. 2; pp. 406 - 412
Main Author Chen, John T.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.06.2008
Blackwell Publishing
Blackwell Publishing Ltd
Subjects
Antineoplastic Agents - therapeutic use
Apoptosis - drug effects
Applied statistics
Biometric Methodology
Biometrics
Bivariate adjustment
Cell Line, Tumor
Clinical trials
Comparative studies
Computer Simulation
Data Interpretation, Statistical
Dosage
Dose response relationship
Dose-response
Dose-Response Relationship, Drug
Estimating techniques
Humans
Inference
Lymphoma
Mathematical procedures
Medical treatment
Models, Biological
Models, Statistical
Neoplasms - drug therapy
Partitioning principle
Research methodology
Simultaneous confidence set
Statistical Distributions
Stepwise procedure
Therapeutic window
Tumors
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Summary:This article proposes a two-stage simultaneous confidence procedure for the comparisons of k pairs of population means, without using multiplicity adjustment of more than two populations. The proposed procedure can be broadly applied to parametric or nonparametric models. It is robust and versatile because its derivation only utilizes a partitioning approach in conjunction with a bivariate adjustment, without any assumption on the underlying distribution. To elucidate the application, the proposed procedure is intertwined with the estimation of the therapeutic window of a drug. It provides confidence limits for the efficacy and the toxicity of the effective doses, highest ineffective dose, safe doses, and lowest unsafe dose, simultaneously. Such estimation information facilitates follow-up studies in clinical trials. As an illustrative example, the new procedure is applied to analyze a data set on molecular cancer therapeutics regarding the apoptotic killing effects of different chemical compounds on two leukemia cell lines.
Bibliography:http://dx.doi.org/10.1111/j.1541-0420.2007.00902.x
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content type line 23
ISSN:0006-341X
1541-0420
DOI:10.1111/j.1541-0420.2007.00902.x