Current intensity‐ and polarity‐specific online and aftereffects of transcranial direct current stimulation: An fMRI study

• Published in: Human brain mapping Vol. 41; no. 6; pp. 1644 - 1666
• Main Authors: Jamil, Asif, Batsikadze, Giorgi, Kuo, Hsiao‐I., Meesen, Raf L. J., Dechent, Peter, Paulus, Walter, Nitsche, Michael A.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.04.2020
• Subjects: arterial spin labeling; Blood flow; Cerebral blood flow; Comparative studies; Computer simulation; Cortex (motor); current intensity; Direct current; Electric fields; Excitability; Finite element method; Functional magnetic resonance imaging; inter‐individual variability; Magnetic fields; Magnetic resonance imaging; motor cortex; Motor evoked potentials; Neuroimaging; Perfusion; Physiological effects; Polarity; Sensorimotor system; Spatial distribution; Spin labeling; transcranial direct current stimulation; Transcranial magnetic stimulation; current intensity; cerebral blood flow; motor cortex; arterial spin labeling; transcranial direct current stimulation; inter-individual variability
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.24901

Transcranial direct current stimulation (tDCS) induces polarity‐ and dose‐dependent neuroplastic aftereffects on cortical excitability and cortical activity, as demonstrated by transcranial magnetic stimulation (TMS) and functional imaging (fMRI) studies. However, lacking systematic comparative studies between stimulation‐induced changes in cortical excitability obtained from TMS, and cortical neurovascular activity obtained from fMRI, prevent the extrapolation of respective physiological and mechanistic bases. We investigated polarity‐ and intensity‐dependent effects of tDCS on cerebral blood flow (CBF) using resting‐state arterial spin labeling (ASL‐MRI), and compared the respective changes to TMS‐induced cortical excitability (amplitudes of motor evoked potentials, MEP) in separate sessions within the same subjects (n = 29). Fifteen minutes of sham, 0.5, 1.0, 1.5, and 2.0‐mA anodal or cathodal tDCS was applied over the left primary motor cortex (M1) in a randomized repeated‐measure design. Time‐course changes were measured before, during and intermittently up to 120‐min after stimulation. ROI analyses indicated linear intensity‐ and polarity‐dependent tDCS after‐effects: all anodal‐M1 intensities increased CBF under the M1 electrode, with 2.0‐mA increasing CBF the greatest (15.3%) compared to sham, while all cathodal‐M1 intensities decreased left M1 CBF from baseline, with 2.0‐mA decreasing the greatest (−9.3%) from sham after 120‐min. The spatial distribution of perfusion changes correlated with the predicted electric field, as simulated with finite element modeling. Moreover, tDCS‐induced excitability changes correlated more strongly with perfusion changes in the left sensorimotor region compared to the targeted hand‐knob region. Our findings reveal lasting tDCS‐induced alterations in cerebral perfusion, which are dose‐dependent with tDCS parameters, but only partially account for excitability changes.