Accurate neurosonographic prediction of brain injury in the surviving fetus after the death of a monochorionic cotwin

• Published in: Ultrasound in obstetrics & gynecology Vol. 27; no. 5; pp. 517 - 521
• Main Authors: Simonazzi, G., Segata, M., Ghi, T., Sandri, F., Ancora, G., Bernardi, B., Tani, G., Rizzo, N., Santini, D., Bonasoni, P., Pilu, G.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.2006; Wiley
• Subjects: Biological and medical sciences; Brain Diseases - diagnostic imaging; Brain Diseases - embryology; cerebral palsy; Child Development; congenital anomalies; Diseases in Twins - diagnostic imaging; Diseases in Twins - embryology; Echoencephalography; Female; Fetal Death; Follow-Up Studies; Gynecology. Andrology. Obstetrics; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Infant, Newborn; Magnetic Resonance Imaging; Medical sciences; multiple pregnancy; Nervous system (semeiology, syndromes); Neurology; Pregnancy; Pregnancy Trimester, Second; prenatal diagnosis; Prognosis; Retrospective Studies; Twins, Monozygotic; Ultrasonography, Prenatal; ultrasound; Sonography; Cerebral palsy; Nervous system diseases; Congenital; Prenatal Diagnosis; Gynecology; Mortality; Central nervous system; congenital anomalies; Obstetrics; Cerebral disorder; Multiple pregnancy; Malformation; Central nervous system disease; Echography; Fetus; Lesion; Predictive factor; Ultrasound
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.2701

Objective To assess the feasibility of the prenatal diagnosis using fetal neurosonography of brain injuries in the surviving fetus after the demise of a monochorionic cotwin. Methods This was a retrospective observational study in the period 1990–2004 of monochorionic twin pregnancies with a single fetal demise. A detailed sonographic evaluation of the intracranial anatomy of the surviving twin had been performed whenever possible using a multiplanar approach and from 1999, fetal magnetic resonance imaging was offered as well. Postnatal follow‐up was obtained in all cases. Results In six of nine cases, abnormal neurosonographic findings were identified including intracranial hemorrhage, brain atrophy, porencephaly and periventricular echogenicities evolving into polymicrogyria. Prenatal diagnosis of brain lesions was confirmed postnatally and all affected infants who survived had severe neurological sequelae. Two fetuses had normal cerebral structures both on the prenatal neurosonogram and on postnatal imaging and were following normal developmental milestones, one at 1 and the other at 5 years of age. In one case the neurosonographic examination was suboptimal and the infant was found at birth to have a porencephalic cyst. Fetal magnetic resonance imaging was performed in two cases and confirmed the ultrasound diagnosis. Conclusions Prenatal neurosonography is a valuable tool for the prediction of neurological outcome in fetuses surviving after the intrauterine death of a monochorionic cotwin. Although our experience is limited, we suggest that magnetic resonance imaging should also be offered. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.