Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances. The hypothalamus, and the arcuate nucleus in particular, is the control center for metabolic...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 695623
Main Authors Huang, Yinqiong, Lin, Xiahong, Lin, Shu
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 09.07.2021
Subjects
arcuate nucleus
Cell and Developmental Biology
clinical intervention strategy perspective
hypothalamus
metabolic syndrome
neuropeptide Y
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Summary:Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances. The hypothalamus, and the arcuate nucleus in particular, is the control center for metabolic homeostasis and energy balance. Neuropeptide Y neurons are particularly abundantly expressed in the arcuate of the hypothalamus, where the blood-brain barrier is weak, such as to critically integrate peripheral metabolic signals with the brain center. Herein, focusing on metabolic syndrome, this manuscript aims to provide an overview of the regulatory effects of Neuropeptide Y on metabolic syndrome and discuss clinical intervention strategy perspectives for neurometabolic disease.
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Reviewed by: Daisuke Kohno, Gunma University, Japan; Nadia Saderi, Autonomous University of San Luis Potosí, Mexico
This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology
Edited by: Zhi-Gang Zhang, Shanghai Jiao Tong University, China
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.695623