Two Antiproliferative Saponins of Tarenna grevei from the Madagascar Dry Forest [1]

Antiproliferative bioassay-guided fractionation of the ethanol extract of the endemic Malagasy Rubiaceous plant Tarenna grevei led to the isolation of two new antiproliferative oxygenated oleanane triterpene saponins. The structures of the two active compounds were elucidated as 23-hydroxylongispino...

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Published inNatural product communications Vol. 7; no. 6; pp. 705 - 708
Main Authors Harinantenaina, Liva, Brodie, Peggy J., Callmander, Martin W., Razafitsalama, L. Jérémie, Rasamison, Vincent E., Rakotobe, Etienne, Kingston, David G. I.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.06.2012
Subjects
Cell Line, Tumor
Cell Proliferation - drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Saponins - chemistry
Saponins - pharmacology
Trees
Antiproliferative
Oxygenated oleanane saponin
A2780
Tarenna
Rubiaceae
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Summary:Antiproliferative bioassay-guided fractionation of the ethanol extract of the endemic Malagasy Rubiaceous plant Tarenna grevei led to the isolation of two new antiproliferative oxygenated oleanane triterpene saponins. The structures of the two active compounds were elucidated as 23-hydroxylongispinogenin 3-O-β-D-glucopyranoside (1) and longispinogenin 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside (3) by analyses of their spectral data including 1D- and 2D-NMR spectroscopy and chemical evidence. Compounds 1 and 3 displayed moderate antiproliferative activity against the A2780 ovarian cancer cell line with IC50 values of 7.6 and 4 μM, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200700604