Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome

• Published in: Fertility and sterility Vol. 94; no. 4; pp. 1437 - 1443
• Main Authors: Kaya, Cemil, M.D, Pabuçcu, Recai, M.D, Koca, Cemile, M.D, Oğuz, A. Kemal, M.D, Erkan, Aycan Fahri, M.D, Korkmaz, Ayhan, M.D, Erbaş, Deniz, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2010; Elsevier
• Subjects: ABP; Adult; Biological and medical sciences; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Case-Control Studies; CRP; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; IL-6; Interleukin-6 - blood; Internal Medicine; Medical sciences; Non tumoral diseases; Obstetrics and Gynecology; PCOS; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - physiopathology; Regression Analysis; Young Adult; CRP; NO; PCOS; IL-6; ABP; Human; Gynecology; Female sterility; Polycystic ovary; Obstetrics; Female genital diseases; Interleukin 6; Ovarian diseases; Cyst; Female; Arterial pressure; Blood pressure; Benign neoplasm; Ambulatory; Woman
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2009.05.055

Objective To determine 24-hour ambulatory blood pressures (ABP) in patients with polycystic ovary syndrome (PCOS) and its relationship with interleukin-6 (IL-6). Design Prospective controlled study. Setting University hospital. Patient(s) Fifty-four PCOS patients. Intervention(s) Ambulatory blood pressure monitoring was conducted. Anthropometric, hormonal, metabolic, and inflammatory parameters, including plasma IL-6, C-reactive protein (CRP), fibrinogen, and nitric oxide (NO), were measured in each subject. Main Outcome Measure(s) Ambulatory blood pressure and plasma IL-6, CRP, fibrinogen, and NO. Result(s) Serum IL-6 levels of PCOS women in the highest systolic blood pressure (SBP) quartile were significantly higher than those of women in the lowest SBP quartile. The high serum IL-6 levels (serum IL-6 level ≥5.1 pg/mL) were associated with a higher probability of raised SBP (≥126 mm Hg), with an odds ratio of 2.2 (95% confidence interval 0.8–7.9). The systolic and diastolic (DBP) blood pressures were significantly related to serum IL-6 levels. The IL-6 levels were positively and significantly correlated with serum CRP levels. Interleukin-6 and CRP were negatively and significantly correlated with serum NO levels. Conlusion(s) The results suggest that raised plasma IL-6 levels may be related to ambulatory SBP and DBP in PCOS.