Aging Enhances Neural Activity in Auditory, Visual, and Somatosensory Cortices: The Common Cause Revisited

• Published in: The Journal of neuroscience Vol. 42; no. 2; pp. 264 - 275
• Main Authors: Alain, Claude, Chow, Ricky, Lu, Jing, Rabi, Rahel, Sharma, Vivek V, Shen, Dawei, Anderson, Nicole D, Binns, Malcolm, Hasher, Lynn, Yao, Dezhong, Freedman, Morris
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 12.01.2022
• Subjects: Adolescent; Adult; Adults; Age; Aged; Aged, 80 and over; Aging; Aging - physiology; Amplitudes; Auditory Cortex - physiology; Brain; Cortex (somatosensory); Domains; Electroencephalography; Evoked Potentials, Somatosensory - physiology; Female; Frequency dependence; Hearing; Humans; Hypotheses; Information processing; Latency; Locking; Male; Males; Middle Aged; Neural networks; Neurons - physiology; Older people; Sensory integration; Sensory perception; Somatosensory Cortex - physiology; Somatosensory stimuli; Visual Cortex - physiology; Visual stimuli; Young Adult; Young adults; evoked potential; aging; common cause; prefrontal; sensory; EEG
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/jneurosci.0864-21.2021

In humans, age-related declines in vision, hearing, and touch coincide with changes in amplitude and latency of sensory-evoked potentials. These age-related differences in neural activity may be related to a common deterioration of supra-modal brain areas (e.g., PFC) that mediate activity in sensory cortices or reflect specific sensorineural impairments that may differ between sensory modalities. To distinguish between these two possibilities, we measured neuroelectric brain activity while 37 young adults (18-30 years, 18 males) and 35 older adults (60-88 years, 20 males) were presented with a rapid randomized sequence of lateralized auditory, visual, and somatosensory stimuli. Within each sensory domain, we compared amplitudes and latencies of sensory-evoked responses, source activity, and functional connectivity (via phase-locking value) between groups. We found that older adults' early sensory-evoked responses were greater in amplitude than those of young adults in all three modalities, which coincided with enhanced source activity in auditory, visual, and somatosensory cortices. Older adults also showed stronger neural synchrony than young adults between superior prefrontal and sensory cortices; and in older adults, the degree of phase synchrony was positively correlated with the magnitude of source activity in sensory areas. Critically, older adults who showed enhanced neural activity in one sensory domain also showed enhanced activity in other modalities. Together, these findings support the common cause hypothesis of aging and highlight the role of prefrontal regions in exerting top-down control over sensory cortices. A prominent theory of aging posits that age-related declines in sensory processing across domains are related to a single common neurobiological mechanism. However, the neural evidence supporting this common cause hypothesis has remained elusive. Our study revealed robust age-related changes in three sensory domains across a range of neural metrics. Importantly, older adults who showed increased neural activity within one sensory domain also showed enhanced neural activity in the other two sensory modalities. No such relation among activity in sensory cortices was observed in young adults. Age-related increases in neural activity in sensory cortices coincided with enhanced neural synchrony between the PFC and sensory cortices, underlining the importance of the PFC in regulating sensory processing.