Genome-based approaches to develop vaccines against bacterial pathogens

• Published in: Vaccine Vol. 27; no. 25; pp. 3245 - 3250
• Main Authors: Serruto, Davide, Serino, Laura, Masignani, Vega, Pizza, Mariagrazia
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier Ltd 26.05.2009; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Applied microbiology; Bacteria; Bacterial Vaccines - genetics; Bacterial Vaccines - immunology; Bacteriology; Biological and medical sciences; Disease; Drug Design; E coli; Fimbriae, Bacterial - immunology; Fundamental and applied biological sciences. Psychology; Genome, Bacterial; Genomes; Genomics; Health risks; Infectious diseases; Meningitis; Meningococcal Vaccines - immunology; Microbiology; Microorganisms; Miscellaneous; Neisseria meningitidis, Serogroup B - immunology; Pathogenesis; Pathogens; Pneumococcal Vaccines - immunology; Proteins; R&D; Research & development; Reverse vaccinology; Streptococcus infections; Streptococcus pyogenes - immunology; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Reverse vaccinology; Genomics; Vaccines; Bacteria; Vaccine; Genome
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2009.01.072

Abstract Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the way to think about vaccine development, enabling the targeting of possible vaccine candidates starting from the genomic information of a single bacterial isolate, with a process named reverse vaccinology. As the genomic era progressed, reverse vaccinology has evolved with a pan-genome approach and multi-strain genome analysis became fundamental for the design of universal vaccines. This review describes the applications of genome-based approaches in the development of new vaccines against bacterial pathogens.