Divergent Transcription: A Driving Force for New Gene Origination?

The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.

Saved in:
Bibliographic Details
Published inCell Vol. 155; no. 5; pp. 990 - 996
Main Authors Wu, Xuebing, Sharp, Phillip A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 21.11.2013
Subjects
Animals
evolution
Evolution, Molecular
gene transcription
genes
Genome
Humans
mammals
Regulatory Sequences, Nucleic Acid
RNA, Untranslated - genetics
transcription
transcription (genetics)
Transcription, Genetic
Online AccessGet full text

Cover

More Information
Summary:The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.
Bibliography:http://dx.doi.org/10.1016/j.cell.2013.10.048
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.10.048