Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau
Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/μl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test...
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Published in | The Pan African medical journal Vol. 29; no. 18; p. 18 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Uganda
African Field Epidemiology Network
2018
The African Field Epidemiology Network The Pan African Medical Journal |
Subjects | |
Online Access | Get full text |
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Summary: | Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/μl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1937-8688 1937-8688 |
DOI: | 10.11604/pamj.2018.29.18.14099 |