Neutrophil extracellular traps and pulmonary fibrosis: an update

Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to the progression of PF. Therefore, understanding...

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Published inJournal of inflammation (London, England) Vol. 20; no. 1; pp. 2 - 9
Main Authors Yan, Suyan, Li, Meiqi, Liu, Baocheng, Ma, Zhenzhen, Yang, Qingrui
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 19.01.2023
BioMed Central
BMC
Subjects
Apoptosis
Collagen
Communicable diseases
Connective tissue diseases
Cystic fibrosis
Cytokines
Development and progression
DNA binding proteins
Etiology
Extracellular matrix
Fibroblasts
Fibrosis
Inflammation
Interstitial lung disease
Leukocytes (neutrophilic)
Lung diseases
Mortality
Neutrophil extracellular traps
Neutrophils
Proteins
Pulmonary fibrosis
Skin
Tumor necrosis factor-TNF
Interstitial lung disease
Neutrophil extracellular traps
Pulmonary fibrosis
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Summary:Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to the progression of PF. Therefore, understanding the pathways by which NETs contribute to the disease is crucial for developing effective treatments. This review focuses on the formation of NETs and the common mechanisms of NETs in PF.
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ISSN:1476-9255
1476-9255
DOI:10.1186/s12950-023-00329-y