Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

• Published in: British journal of cancer Vol. 102; no. 12; pp. 1692 - 1698
• Main Authors: Park, J-Y, Kim, D-Y, Kim, J-H, Kim, Y-M, Kim, Y-T, Nam, J-H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.06.2010; Nature Publishing Group
• Subjects: 692/308/409; 692/699/67/1517/1371; 692/700/565/545/546; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Clinical Study; Disease-Free Survival; Drug Resistance; Epidemiology; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Hysterectomy - methods; Lymphatic Metastasis; Medical sciences; Middle Aged; Molecular Medicine; Neoplasm Recurrence, Local - pathology; Oncology; Prognosis; Recurrence; Treatment Outcome; Tumors; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - surgery; radical hysterectomy; adenocarcinoma; prognosis; early-stage cervical cancer; squamous cell carcinoma; Human; Skin disease; Squamous cell carcinoma; Basal cell carcinoma; Prognosis; Early stage; Malignant tumor; Hysterectomy; Female genital diseases; Cancerology; Treatment; Surgery; Cervical adenocarcinoma; Uterine cervix diseases; Cervical cancer; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6605705

Background: To determine the prognostic factors and treatment outcomes of patients with early-stage adenocarcinoma (AdCa) of uterine cervix who underwent radical hysterectomy (RH). Methods: Patients with early-stage squamous cell carcinoma (SCCa) of the uterine cervix who underwent RH were compared with patients with AdCa by multivariate analysis. Results: A total of 1218 patients were eligible, of which 996 (81.8%) had SCCa and 222 (18.2%) had AdCa. In multivariate analysis, parametrial involvement and lymph node metastasis were significant factors for both recurrence-free survival(RFS) and overall survival (OS) of patients with AdCa, whereas age, tumour size, parametrial involvement and lymph node metastasis were significant factors for both RFS and OS of patients with SCCa. After adjusting for significant prognostic factors, patients with AdCa had significantly poorer RFS (odds ratio (OR)=2.07, 95% confidence interval (CI)=1.37–3.12, P =0.001) and OS (OR=2.56, 95% CI=1.65–3.96, P <0.001) than patients with SCCa. Recurrence outside the pelvis was more frequent in AdCa than in those with SCCa (75 vs 57.8%, P =0.084). Conclusion(s): Although RH is still acceptable for treatment of patients with AdCa, a more effective systemic adjuvant therapy is required.