The role of pregnane X receptor (PXR) in substance metabolism

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 959902
• Main Authors: Lv, Ye, Luo, Yi-Yang, Ren, Hui-Wen, Li, Cheng-Jie, Xiang, Zhi-Xin, Luan, Zhi-Lin
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 16.08.2022
• Subjects: bile acid; Endocrinology; glycometabolism; lipid metabolism; metabolism; nuclear receptor; pregnane X receptor (PXR)

As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is a ligand-activated transcription factor that plays a crucial role in the metabolism of xenobiotics and endobiotics in mammals. The tissue distribution of PXR is parallel to its function with high expression in...