Hepatic Veno-occlusive Disease and Human Herpes Virus 7 Infection in Primary Agammaglobulinemia

• Published in: The Journal of pediatrics Vol. 154; no. 2; pp. 299 - 302
• Main Authors: Soden, Jason S., MD, Narkewicz, Michael R., MD, Haas, Joel E., MD, Sokol, Ronald J., MD
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Mosby, Inc 01.02.2009; Elsevier
• Subjects: Adolescent; Agammaglobulinemia - complications; Agammaglobulinemia - drug therapy; Biological and medical sciences; DNA, Viral - blood; General aspects; Hepatic Veno-Occlusive Disease - complications; Hepatic Veno-Occlusive Disease - surgery; Herpesvirus 7, Human - genetics; Human viral diseases; Humans; Immunoglobulins, Intravenous - therapeutic use; Infectious diseases; Liver - pathology; Liver Failure - etiology; Liver Transplantation; Male; Medical sciences; Pediatrics; Roseolovirus Infections - complications; Roseolovirus Infections - diagnosis; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Polymerase chain reaction; Veno-occlusive disease; Human herpes virus; HHV; BMT; Bone marrow transplantation; VOD; XLA; X-linked agammaglobulinemia; PCR; Infection; Human; Immunopathology; Pediatrics; Venoocclusive disease; Viral disease; Agammaglobulinemia; Primary; Herpes; Digestive diseases; Hepatic disease
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2008.08.048

Hepatobiliary disease has been described in Bruton's x-linked agammaglobulinemia; however, veno-occlusive disease has not been reported in this setting. We report a case of end-stage liver disease in a patient with x-linked agammaglobulinemia who was found to have VOD and evidence of human herpes virus 7 infection in the explanted liver after transplantation.