miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7

• Published in: Tumor biology Vol. 35; no. 11; pp. 10731 - 10736
• Main Authors: Ma, Ying, She, Xing-guo, Ming, Ying-zi, Wan, Qi-quan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.11.2014; Springer Nature B.V
• Subjects: Apoptosis; Biomedical and Life Sciences; Biomedicine; Blotting, Western; Cancer Research; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell adhesion & migration; Cell growth; Cell Movement; Cell Proliferation; Gene expression; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Luciferases - metabolism; MicroRNAs - genetics; Real-Time Polymerase Chain Reaction; Research Article; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; SOXF Transcription Factors - genetics; SOXF Transcription Factors - metabolism; Tumor Cells, Cultured; Hepatocellular carcinoma; Proliferation; miR-24; SOX7; Migration; Invasion
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-014-2018-6

Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.