Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality From Diarrhea

In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality....

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Bibliographic Details
Published inThe Journal of infectious diseases Vol. 215; no. 11; pp. 1666 - 1672
Main Authors Burnett, Eleanor, Jonesteller, Christine L., Tate, Jacqueline E., Yen, Catherine, Parashar, Umesh D.
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.06.2017
Subjects
Child, Preschool
Diarrhea - mortality
Diarrhea - prevention & control
Diarrhea - virology
Emergency Service, Hospital
Gastroenteritis - mortality
Gastroenteritis - prevention & control
Gastroenteritis - virology
Hospitalization
Humans
Infant
Infant, Newborn
Rotavirus - immunology
Rotavirus Infections - mortality
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
Rotavirus Vaccines - administration & dosage
Vaccination
VIRUSES
diarrhea
rotavirus
Rotavirus vaccine
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Summary:In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. We used standardized guidelines (PRISMA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre– and post–vaccine introduction surveillance data. We identified 57 articles from 27 countries. Among children <5 years of age, the median percentage reduction in AGE hospitalizations was 38% overall and 41%, 30%, and 46% in countries with low, medium, and high child mortality, respectively. Hospitalizations and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall and 71%, 59%, and 60% in countries with low, medium, and high child mortality, respectively. Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotavirus and all-cause AGE.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jix186