Global burden of osteoarthritis in adults aged 30 to 44 years, 1990 to 2019: results from the Global Burden of Disease Study 2019

• Published in: BMC musculoskeletal disorders Vol. 25; no. 1; p. 303
• Main Authors: He, Yixiang, Jiang, Wenkai, Wang, Wenji
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.04.2024; BioMed Central; BMC
• Subjects: Age; Age groups; Aging; Arthritis; Care and treatment; Complications and side effects; Cost of Illness; Diagnosis; Disease prevention; Female; Females; Gender; Global Burden of Disease; Global Health; Health aspects; Humans; Incidence; Male; Males; Mortality; Obesity; Older people; Osteoarthritis; Osteoarthritis - diagnosis; Osteoarthritis - epidemiology; Physiological aspects; Population; Prevalence; Quality-Adjusted Life Years; Risk factors; Sociodemographics; Software; Statistical analysis; Trends; Years lived with disability; Young Adult; Young adults; China; Global Burden of Disease; Prevalence; Years lived with disability; Osteoarthritis; Young adult; Incidence
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-024-07442-w

Osteoarthritis (OA) is a common orthopedic disorder, and its incidence has been increasing among young adults in recent years. The purpose of this study is to investigate the global, regional, and national trends in OA burden and variation among individuals aged 30 to 44 from 1990 to 2019. Data on the incidence, prevalence, and years lived with disability (YLDs) related to OA were sourced from the Global Burden of Disease Study 2019 among individuals aged 30 to 44. These measures were stratified by gender, region, country, and socio-demographic index (SDI). Additionally, we analyzed YLDs attributable to risk factors. In 2019, there were a total of 32,971,701 cases of OA among individuals aged 30 to 44 years worldwide, with an additional 7,794,008 new incident cases reported. OA of the knee was the primary contributor to both incidence and prevalence rates over the past three decades. From 1990 to 2019, both males and females in countries with high SDI and high-middle SDI showed upward trends in age-standardized incidence, prevalence, and YLDs rates. In 2019, the United States of America had the highest age-standardized incidence, prevalence, and YLDs rates. Elevated body-mass index (BMI) was found to be the most prevalent risk factor for osteoarthritis-related YLDs. Age-standardized YLDs rates were positively associated with SDI. OA remains a significant disease burden on individuals aged 30 to 44, with modifiable risk factors such as unhealthy lifestyle and obesity representing key targets for future interventions aimed at reducing the impact of this condition on younger generations.