Regulation of apoptosis by viral gene products

Apoptosis is the process whereby individual cells of multicellular organisms undergo systematic self-destruction in response to a wide variety of stimuli. Apoptosis is a genetically controlled preprogrammed event which eliminates cells during development when they have become redundant or which func...

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Bibliographic Details
Published inJournal of virology Vol. 71; no. 3; pp. 1739 - 1746
Main Authors Teodoro, J G, Branton, P E
Format Journal Article
LanguageEnglish
Published United States 01.03.1997
Subjects
Animals
Apoptosis - physiology
Humans
Sindbis virus
Tumor Suppressor Protein p53 - metabolism
Viral Proteins - physiology
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Summary:Apoptosis is the process whereby individual cells of multicellular organisms undergo systematic self-destruction in response to a wide variety of stimuli. Apoptosis is a genetically controlled preprogrammed event which eliminates cells during development when they have become redundant or which functions as an emergency response after radiation damage, viral infection, or aberrant growth induced by the activation of oncogenes. The purpose of this review is to summarize recent information on the induction and suppression of apoptosis by viral products as well as to propose how this knowledge may provide insights into basic cell biology and offer the potential of new therapeutic applications. A recent comprehensive review by Shen and Shenk (75) also deals with some aspects of the subjects covered below.
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ISSN:0022-538X
1098-5514
DOI:10.1128/jvi.71.3.1739-1746.1997