Indole inhibited the expression of csrA gene in Escherichia coli
Indole is a very important signal molecule which plays multiple regulatory roles in many physiological and biochemical processes of bacteria, but up to now, the reasons for its wide range of functions have not been revealed. In this study, we found that indole inhibits the motility, promotes glycoge...
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| Published in | Journal of general and applied microbiology Vol. 69; no. 5; pp. 239 - 248 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
01.01.2023
Japan Science and Technology Agency |
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| Online Access | Get full text |
| ISSN | 0022-1260 1349-8037 |
| DOI | 10.2323/jgam.2023.06.007 |
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| Abstract | Indole is a very important signal molecule which plays multiple regulatory roles in many physiological and biochemical processes of bacteria, but up to now, the reasons for its wide range of functions have not been revealed. In this study, we found that indole inhibits the motility, promotes glycogen accumulation and enhances starvation resistance of Escherichia coli. However, the regulatory effects of indole became insignificant while the global csrA gene was mutated. To reveal the regulatory relationship between indole and csrA, we studied the effects of indole on the transcription level of csrA, flhDC, glgCAP and cstA, and also the sensing of the promoters of the genes on indole. It was found that indole inhibited the transcription of csrA, and only the promoter of the csrA gene can sense indole. Namely, indole indirectly regulated the translation level of FlhDC, GlgCAP and CstA. These data indicates that indole regulation is related with the regulation of CsrA, which may throw light on the regulation mechanism research of indole. |
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| AbstractList | Indole is a very important signal molecule which plays multiple regulatory roles in many physiological and biochemical processes of bacteria, but up to now, the reasons for its wide range of functions have not been revealed. In this study, we found that indole inhibits the motility, promotes glycogen accumulation and enhances starvation resistance of Escherichia coli. However, the regulatory effects of indole became insignificant while the global csrA gene was mutated. To reveal the regulatory relationship between indole and csrA, we studied the effects of indole on the transcription level of csrA, flhDC, glgCAP and cstA, and also the sensing of the promoters of the genes on indole. It was found that indole inhibited the transcription of csrA, and only the promoter of the csrA gene can sense indole. Namely, indole indirectly regulated the translation level of FlhDC, GlgCAP and CstA. These data indicates that indole regulation is related with the regulation of CsrA, which may throw light on the regulation mechanism research of indole. |
| ArticleNumber | 2023.06.007 |
| Author | Guo, Huiying Shi, Zhenxia Zheng, Jing Zuo, Guocai Zhou, Zhiguo Sun, Zemin Feng, Yongjun |
| Author_xml | – sequence: 1 fullname: Zuo, Guocai organization: School of Life Science, Langfang Normal University – sequence: 1 fullname: Shi, Zhenxia organization: School of Life Science, Langfang Normal University – sequence: 1 fullname: Guo, Huiying organization: School of Life Science, Langfang Normal University – sequence: 1 fullname: Sun, Zemin organization: School of Life Science, Beijing Institute of Technology – sequence: 1 fullname: Zheng, Jing organization: School of Life Science, Langfang Normal University – sequence: 1 fullname: Feng, Yongjun organization: School of Life Science, Beijing Institute of Technology – sequence: 1 fullname: Zhou, Zhiguo organization: School of Life Science, Langfang Normal University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37423745$$D View this record in MEDLINE/PubMed |
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| References_xml | – reference: Fields, J. A. and Thompson, S. A. (2012) Campylobacter jejuni CsrA complements an Escherichia coli csrA mutation for the regulation of biofilm formation, motility and cellular morphology but not glycogen accumulation. BMC Microbiol., 12, 233. – reference: Kim, J. and Park, W. (2015) Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentration? J. Microbiol. (Seoul, Korea), 53, 421–428. – reference: Baker, C. S., Morozov, I., Suzuki, K., Romeo, T., and Babitzke, P. (2002) CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli. Mol. Microbiol., 44, 1599–1610. – reference: Zheng, J., Xia, Y., Liu, Q., He, X., Yu, J., and Feng, Y. (2019b) Extracellular DNA enhances the formation and stability of symplasmata in Pantoea agglomerans YS19. J. Gen. Appl. Microbiol., 65, 11–17. – reference: Oshiro, R. T., Rajendren, S., Hundley, H. A., and Kearns, D. B. (2019) Robust Stoichiometry of FliW-CsrA Governs Flagellin Homeostasis and Cytoplasmic Organization in Bacillus subtilis. mBio, 10, e00533-19. – reference: Radwanski, E. R. and Last, R. L. (1995) Tryptophan biosynthesis and metabolism: biochemical and molecular genetics. Plant Cell, 7, 921–934. – reference: Gratani, F. L., Englert, T., Nashier, P., Sass, P., Czech, L., Neumann, N., Doello, S., Mann, P., Blobelt, R., Alberti, S., Forchhammer, K., Bange, G., Höfer, K., and Macek, B. (2023) E. coli Toxin YjjJ (HipH) Is a Ser/Thr Protein Kinase That Impacts Cell Division, Carbon Metabolism, and Ribosome Assembly. mSystems, 8, e0104322. – reference: Sun, Z., Zhou, N., Zhang, W., Xu, Y., and Yao, Y. F. (2022) Dual role of CsrA in regulating the hemolytic activity of Escherichia coli O157:H7. Virulence, 13, 859–874. – reference: Yakhnin, H., Pandit, P., Petty, T. J., Baker, C. S., Romeo, T., and Babitzke, P. (2007) CsrA of Bacillus subtilis regulates translation initiation of the gene encoding the flagellin protein (hag) by blocking ribosome binding. Mol. Microbiol., 64, 1605–1620. – reference: Kovach, M. E., Elzer, P. H., Hill, D. S., Robertson, G. T., Farris, M. A., Roop, R. M., 2nd, and Peterson, K. M. (1995) Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes. Gene, 166, 175–176. – reference: Samad, T., Billings, N., Birjiniuk, A., Crouzier, T., Doyle, P. S., and Ribbeck, K. (2017) Swimming bacteria promote dispersal of non-motile staphylococcal species. ISME J., 11, 1933–1937. – reference: Bongaerts, J., Krämer, M., Müller, U., Raeven, L., and Wubbolts, M. (2001) Metabolic engineering for microbial production of aromatic amino acids and derived compounds. Metab. Eng., 3, 289–300. – reference: Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., and Mori, H. 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| SubjectTerms | csrA E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene expression Gene Expression Regulation, Bacterial Glycogen Glycogens Indole Indoles Indoles - pharmacology Regulation Repressor Proteins - genetics Repressor Proteins - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism |
| Title | Indole inhibited the expression of csrA gene in Escherichia coli |
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