Anorexia, a recessive mutation causing starvation in preweanling mice

A new autosomal recessive lethal mutation in mice, anorexia (anx), located close to pallid (pa) on chromosome (chr) 2, is described. Mutant mice are characterized by growth failure, an emaciated appearance, and abnormal behavior including headweaving, body tremors, uncoordinated gait, and hyperactiv...

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Bibliographic Details
Published inThe Journal of heredity Vol. 75; no. 6; pp. 468 - 472
Main Authors Maltais, L.J, Lane, P.W, Beamer, W.G
Format Journal Article
LanguageEnglish
Published United States 01.11.1984
Subjects
Animal Population Groups
Animals
Animals, Suckling
anorexia
Anorexia - genetics
Anorexia - veterinary
diet-related diseases
Disease Models, Animal
Failure to Thrive
Feeding and Eating Disorders - veterinary
Female
Genes, Lethal
Genes, Recessive
Humans
lethal genes
Male
Mice
Mice, Mutant Strains - genetics
preweaning period
recessive lethals
Rodent Diseases - genetics
starvation
Sucking Behavior
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Summary:A new autosomal recessive lethal mutation in mice, anorexia (anx), located close to pallid (pa) on chromosome (chr) 2, is described. Mutant mice are characterized by growth failure, an emaciated appearance, and abnormal behavior including headweaving, body tremors, uncoordinated gait, and hyperactivity during the late preweanling period. Data suggest that the mutant mice are not ingesting the levels of nutrients necessary to sustain life. This mutation may provide an important tool for studying the neurobiology of suckling behavior in the preweanling animal.
ISSN:0022-1503
1465-7333
DOI:10.1093/oxfordjournals.jhered.a109987