Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)

• Published in: Placenta (Eastbourne) Vol. 35; no. 5; pp. 331 - 333
• Main Authors: Feng, L., Antczak, B.C., Lan, L., Grotegut, C.A., Thompson, J.L., Allen, T.K., Murtha, A.P.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.05.2014; Elsevier
• Subjects: Amnion - metabolism; Biological and medical sciences; Chorion - metabolism; Decidua - metabolism; Embryology: invertebrates and vertebrates. Teratology; Expression; Extraembryonic Membranes - metabolism; Female; Fetal membrane cells; Fetal Membranes, Premature Rupture - metabolism; Fundamental and applied biological sciences. Psychology; Gestational Age; Humans; Internal Medicine; Membrane Proteins - metabolism; Obstetrics and Gynecology; PGRMC1; PPROM; Pregnancy; Receptors, Progesterone - metabolism; PGRMC1; Fetal membrane cells; PPROM; Expression; Human; Vertebrata; Membrane receptor; Mammalia; Pregnancy disorders; Fetal membrane; Premature rupture of membrane; Delivery disorders; Female; Fetoplacental membrane; Hormonal receptor
• ISSN: 0143-4004; 1532-3102; 1532-3102
• DOI: 10.1016/j.placenta.2014.03.008

PGRMC1 function is implicated in maintaining fetal membrane (FM) integrity. PGRMC1 was detectable primarily in the cytoplasm of FM cells and was actively regulated in FMs and relevant for PGRMC1-mediated progesterone action. By cell type, PGRMC1 expression was higher in amnion and chorion compared with decidua. By clinical phenotype, PGRMC1 expression was higher among preterm-no-labor and term-no-labor subjects compared to PPROM. PGRMC1 expression appears to be diminished in PPROM subjects.