Aging microglia

• Published in: Cellular and molecular life sciences : CMLS Vol. 80; no. 5; p. 126
• Main Authors: Antignano, Ignazio, Liu, Yingxiao, Offermann, Nina, Capasso, Melania
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2023; Springer Nature B.V
• Subjects: Age; Aging; Alzheimer's disease; Animal cognition; Animal models; Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain; Brain-Gut Axis; Cell Biology; Cellular Senescence; Cytokines; Genotype & phenotype; Humans; Life Sciences; Macrophages; Microglia; Monocytes; Morphology; Neurodegeneration; Neurodegenerative diseases; neuroglia; Oxidative Stress; phenotype; Phenotypes; Proteins; Review; rodents; Signal Transduction; therapeutics; Aging; Neuroinflammation; Human microglia; Senescence; RNAseq; Microglia

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by mi...