Aging microglia

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by mi...

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Published inCellular and molecular life sciences : CMLS Vol. 80; no. 5; p. 126
Main Authors Antignano, Ignazio, Liu, Yingxiao, Offermann, Nina, Capasso, Melania
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.05.2023
Springer Nature B.V
Subjects
Age
Aging
Alzheimer's disease
Animal cognition
Animal models
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Brain-Gut Axis
Cell Biology
Cellular Senescence
Cytokines
Genotype & phenotype
Humans
Life Sciences
Macrophages
Microglia
Monocytes
Morphology
Neurodegeneration
Neurodegenerative diseases
neuroglia
Oxidative Stress
phenotype
Phenotypes
Proteins
Review
rodents
Signal Transduction
therapeutics
Aging
Neuroinflammation
Human microglia
Senescence
RNAseq
Microglia
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Summary:Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.
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ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-023-04775-y