Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 12; no. 4; pp. 623 - 628
• Main Authors: Shah, Akeesha A., Lamarre, Eric D., Bishop, Justin A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2018
• Subjects: Adult; Aged; Carcinoma, Adenoid Cystic - pathology; Carcinoma, Adenoid Cystic - virology; Case Report; Dentistry; Female; Humans; Medicine; Medicine & Public Health; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - virology; Oral and Maxillofacial Surgery; Otorhinolaryngology; Papillomavirus Infections - complications; Paranasal Sinus Neoplasms - pathology; Paranasal Sinus Neoplasms - virology; Pathology; Multiphenotypic sinonasal carcinoma; Human papillomavirus; Sinonasal carcinoma; Carcinoma with adenoid cystic-like features; Adenoid cystic carcinoma
• ISSN: 1936-055X; 1936-0568
• DOI: 10.1007/s12105-018-0895-5

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior. Herein we report our experience with a case of HPV-related multiphenotypic sinonasal carcinoma that was initially classified as adenoid cystic carcinoma in the 1980s. The patient recurred after a 30-year disease free interval. RNA in situ hybridization confirmed the presence of high-risk HPV in both her recurrence and her initial tumor in the 1980s, which allowed for reclassification as HPV-related multiphenotypic sinonasal carcinoma. Our case adds to the literature of this relatively newly described entity and supports the indolent clinical behavior of this neoplasm but also demonstrates a potential for very late local recurrence.