Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

• Published in: Archives of Endocrinology and Metabolism Vol. 61; no. 5; pp. 455 - 459
• Main Authors: Ademoglu, Esra Nur, Gorar, Suheyla, Keskin, Muge, Carlioglu, Ayse, Ucler, Rifki, Erdamar, Husamettin, Culha, Cavit, Aral, Yalcin
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.09.2017; Brazilian Society of Endocrinology and Metabolism
• Subjects: Adult; Biomarkers - blood; Body Mass Index; Calcium-Binding Proteins - blood; Case-Control Studies; Cross-Sectional Studies; Diabetes, Gestational - blood; Diabetes, Gestational - diagnosis; DNA-Binding Proteins - blood; Enzyme-Linked Immunosorbent Assay; Fasting - blood; Female; Gestational Age; Gestational diabetes; Glucose Tolerance Test; Humans; insulin resistance; Nerve Tissue Proteins - blood; nesfatin-1; Pregnancy
• ISSN: 2359-3997; 2359-4292; 2359-4292; 2359-3997
• DOI: 10.1590/2359-3997000000288

To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.