The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing hormone antagonist cycles: a prospective clinical trial

• Published in: Fertility and sterility Vol. 94; no. 2; pp. 761 - 763
• Main Authors: Kahraman, Semra, M.D, Karagozoglu, S. Hale, M.D, Karlkaya, Guvenc, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2010; Elsevier
• Subjects: Administration, Intravaginal; Adult; Biological and medical sciences; Diseases of the digestive system; Embryo Transfer; Female; Fertilization in Vitro - methods; Gels; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gynecology. Andrology. Obstetrics; Humans; Injections, Intramuscular; Internal Medicine; Luteal Phase - drug effects; Medical sciences; Obstetrics and Gynecology; Ovulation Induction - methods; Pregnancy; Progesterone - administration & dosage; Progestins - administration & dosage; Prospective Studies; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Gynecology; Gonadotropin RH; Vagina; Obstetrics; Progestagen; Luteal phase; Diet therapy; Efficiency; Clinical trial; Muscle; Antagonist; Progesterone; Supplementation; Sex steroid hormone; Comparative study
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2009.10.004

We compared the efficiency of progesterone vaginal gel (PVG) with intramuscular progesterone (IMP) supplementation for luteal phase support after in vitro fertilization and embryo transfer in gonadotropin-releasing hormone (GnRH) antagonist cycles. The treatment outcomes were similar for PVG and IMP for luteal support in GnRH-antagonist protocols. With its ease of use, high tolerability by patients, and fewer side effects, PVG can be a successful alternative to IMP.