Development, manufacturing and application of double-sided flexible implantable microelectrodes
Many neuroprosthetic applications require the use of very small, flexible multi-channel microelectrodes (e.g. polyimide-based film-like electrodes) to fit anatomical constraints. By arranging the electrode contacts on both sides of the polyimide film, selectivity can be further increased without inc...
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Published in | Biomedical microdevices Vol. 16; no. 6; pp. 837 - 850 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.12.2014
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Many neuroprosthetic applications require the use of very small, flexible multi-channel microelectrodes (e.g. polyimide-based film-like electrodes) to fit anatomical constraints. By arranging the electrode contacts on both sides of the polyimide film, selectivity can be further increased without increasing size. In this work, two approaches to create such double-sided electrodes are described and compared:
sandwich electrodes
prepared by precisely gluing two single-sided structures together, and
monolithic electrodes
created using a new double-sided photolithography process. Both methods were successfully applied to manufacture double-sided electrodes for stimulation of the vestibular system. In a case study, the electrodes were implanted in the semicircular canals of three guinea pigs and proven to provide electrical stimulation of the vestibular nerve. For both the
monolithic electrodes
and the
sandwich electrodes
, long-term stability and functionality was observed over a period of more than 12 months. Comparing the two types of electrodes with respect to the manufacturing process, it can be concluded that
monolithic electrodes
are the preferred solution for very thin electrodes (<20 μm), while
sandwich electrode
technology is especially suitable for thicker electrodes (40–50 μm). |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1387-2176 1572-8781 |
DOI: | 10.1007/s10544-014-9887-8 |