Development, manufacturing and application of double-sided flexible implantable microelectrodes

• Published in: Biomedical microdevices Vol. 16; no. 6; pp. 837 - 850
• Main Authors: Poppendieck, Wigand, Sossalla, Adam, Krob, Marc-Oliver, Welsch, Christine, Nguyen, T. A. Khoa, Gong, Wangsong, DiGiovanna, Jack, Micera, Silvestro, Merfeld, Daniel M., Hoffmann, Klaus-Peter
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2014; Springer Nature B.V
• Subjects: Animals; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biophysics; Electric Stimulation - instrumentation; Electric Stimulation - methods; Electrodes; Electrodes, Implanted; Engineering; Engineering Fluid Dynamics; Guinea Pigs; Humans; Membranes, Artificial; Microelectrodes; Nanotechnology; Photolithography; Polyimide resins; Prosthesis Design; Resins, Synthetic - chemistry; Semicircular canals; Stability; Stimulation; Transplants & implants; Vestibular Nerve; Microelectromechanical systems; Neural microtechnology; Vestibular implant; Polyimides; Neural prosthesis
• ISSN: 1387-2176; 1572-8781
• DOI: 10.1007/s10544-014-9887-8

Many neuroprosthetic applications require the use of very small, flexible multi-channel microelectrodes (e.g. polyimide-based film-like electrodes) to fit anatomical constraints. By arranging the electrode contacts on both sides of the polyimide film, selectivity can be further increased without increasing size. In this work, two approaches to create such double-sided electrodes are described and compared: sandwich electrodes prepared by precisely gluing two single-sided structures together, and monolithic electrodes created using a new double-sided photolithography process. Both methods were successfully applied to manufacture double-sided electrodes for stimulation of the vestibular system. In a case study, the electrodes were implanted in the semicircular canals of three guinea pigs and proven to provide electrical stimulation of the vestibular nerve. For both the monolithic electrodes and the sandwich electrodes , long-term stability and functionality was observed over a period of more than 12 months. Comparing the two types of electrodes with respect to the manufacturing process, it can be concluded that monolithic electrodes are the preferred solution for very thin electrodes (<20 μm), while sandwich electrode technology is especially suitable for thicker electrodes (40–50 μm).