Hepatitis C virus infection and myositis: a virus localization study

We report a case of myositis associated with chronic hepatitis C virus infection. Muscle biopsy and immunohistochemistry showed perifascicular atrophy, few necrotic and regenerating fibres, scarce perivascular infiltrates, deposits of immunoglobulin G, C3, fibrinogen and MAC in muscle vessel walls,...

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Published inNeuromuscular disorders : NMD Vol. 13; no. 1; pp. 68 - 71
Main Authors Di Muzio, A., Bonetti, B., Capasso, M., Panzeri, L., Pizzigallo, E., Rizzuto, N., Uncini, A.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 2003
Subjects
Aged
Female
Fibrinogen - metabolism
Hepacivirus - metabolism
Hepatitis C virus
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - virology
Humans
Immunoglobulin G - metabolism
Immunohistochemistry
In Situ Hybridization
Major Histocompatibility Complex - physiology
Microscopy, Electron
Myositis
Myositis - complications
Myositis - pathology
Myositis - virology
Polymerase Chain Reaction
RNA, Messenger - analysis
RNA, Viral - analysis
Viral Nonstructural Proteins - metabolism
Virus localization
Hepatitis C virus
Myositis
Virus localization
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Summary:We report a case of myositis associated with chronic hepatitis C virus infection. Muscle biopsy and immunohistochemistry showed perifascicular atrophy, few necrotic and regenerating fibres, scarce perivascular infiltrates, deposits of immunoglobulin G, C3, fibrinogen and MAC in muscle vessel walls, and non-uniform expression of major histocompatibility complex-I antigens among muscle fibres. Hepatitis C virus NS3 antigen and hepatitis C virus RNA were detected in infiltrating cells but not within muscle fibres or endothelial cells. Our findings suggest that humoral-mediated immune mechanisms, not directly related to hepatitis C virus infection of muscle structures, may sustain the local inflammatory reaction in this patient.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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ISSN:0960-8966
1873-2364
DOI:10.1016/S0960-8966(02)00184-0