Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea
A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/Californi...
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| Published in | Immune Network Vol. 16; no. 5; pp. 311 - 315 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Association of Immunobiologists
2016
대한면역학회 The Korean Association of Immunologists |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1598-2629 2092-6685 |
| DOI | 10.4110/in.2016.16.5.311 |
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| Abstract | A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms. |
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| AbstractList | A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms. A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms. A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms. KCI Citation Count: 1 |
| Author | Daesub Song Sung Jae Kim Minjoo Yeom Hyoung Joon Moon Bo Kyu Kang Jin Sik Oh Bong-Kyun Park Sang Yoon Han Woonsung Na |
| AuthorAffiliation | 3 MEDIAN Diagnostics Inc., Chuncheon 24339, Korea 2 Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea 4 Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine, and School of Agricultural Biotechnology, BK21 Program for Veterinary Science, Seoul National University, Seoul 08826, Korea 1 Research Unit, Green Cross Veterinary Products, Yongin 17066, Korea |
| AuthorAffiliation_xml | – name: 3 MEDIAN Diagnostics Inc., Chuncheon 24339, Korea – name: 4 Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine, and School of Agricultural Biotechnology, BK21 Program for Veterinary Science, Seoul National University, Seoul 08826, Korea – name: 2 Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea – name: 1 Research Unit, Green Cross Veterinary Products, Yongin 17066, Korea |
| Author_xml | – sequence: 1 givenname: Hyoung Joon surname: Moon fullname: Moon, Hyoung Joon organization: Research Unit, Green Cross Veterinary Products, Yongin 17066, Korea – sequence: 2 givenname: Jin Sik surname: Oh fullname: Oh, Jin Sik organization: MEDIAN Diagnostics Inc., Chuncheon 24339, Korea – sequence: 4 givenname: Minjoo surname: Yeom fullname: Yeom, Minjoo organization: Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea – sequence: 5 givenname: Sang Yoon surname: Han fullname: Han, Sang Yoon organization: Research Unit, Green Cross Veterinary Products, Yongin 17066, Korea – sequence: 6 givenname: Sung Jae surname: Kim fullname: Kim, Sung Jae organization: Research Unit, Green Cross Veterinary Products, Yongin 17066, Korea – sequence: 7 givenname: Bong Kyun surname: Park fullname: Park, Bong Kyun organization: Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine, and School of Agricultural Biotechnology, BK21 Program for Veterinary Science, Seoul National University, Seoul 08826, Korea – sequence: 8 givenname: Dae Sub surname: Song fullname: Song, Dae Sub organization: Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea – sequence: 9 givenname: Bo Kyu surname: Kang fullname: Kang, Bo Kyu organization: Research Unit, Green Cross Veterinary Products, Yongin 17066, Korea |
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| Cites_doi | 10.1038/nature08260 10.1128/JCM.41.7.3198-3205.2003 10.1016/j.jcpa.2004.09.008 10.3201/eid1604.091636 10.1136/vr.c7464 10.1016/S0065-3527(08)00403-X 10.1007/s007050170002 10.1016/j.meegid.2015.06.005 10.1099/vir.0.014480-0 10.1128/JCM.00053-10 10.1371/journal.pone.0009068 10.1136/vr.164.24.760 |
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| Title | Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea |
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