Diversity of Macrophages in Lung Homeostasis and Diseases

Lung macrophages play important roles in the maintenance of homeostasis, pathogen clearance and immune regulation. The different types of pulmonary macrophages and their roles in lung diseases have attracted attention in recent years. Alveolar macrophages (AMs), including tissue-resident alveolar ma...

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Published inFrontiers in immunology Vol. 12; p. 753940
Main Authors Hou, Fei, Xiao, Kun, Tang, Li, Xie, Lixin
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 24.09.2021
Subjects
COVID-19
fibrosis
Immunology
infection
inflammation
macrophage
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Summary:Lung macrophages play important roles in the maintenance of homeostasis, pathogen clearance and immune regulation. The different types of pulmonary macrophages and their roles in lung diseases have attracted attention in recent years. Alveolar macrophages (AMs), including tissue-resident alveolar macrophages (TR-AMs) and monocyte-derived alveolar macrophages (Mo-AMs), as well as interstitial macrophages (IMs) are the major macrophage populations in the lung and have unique characteristics in both steady-state conditions and disease states. The different characteristics of these three types of macrophages determine the different roles they play in the development of disease. Therefore, it is important to fully understand the similarities and differences among these three types of macrophages for the study of lung diseases. In this review, we will discuss the physiological characteristics and unique functions of these three types of macrophages in acute and chronic lung diseases. We will also discuss possible methods to target macrophages in lung diseases.
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Reviewed by: Na Xie, Independent Researcher, Chengdu, China; Rahul Mahida, University of Birmingham, United Kingdom; Stephen Tung Yeung, Cornell University, United States
Edited by: Chaofeng Han, Second Military Medical University, China
These authors have contributed equally to this work
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.753940