Feature-Specific Awake Reactivation in Human V1 after Visual Training

• Published in: The Journal of neuroscience Vol. 38; no. 45; pp. 9648 - 9657
• Main Authors: Bang, Ji Won, Sasaki, Yuka, Watanabe, Takeo, Rahnev, Dobromir
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 07.11.2018
• Subjects: Activation; Activity patterns; Adult; Brain; Consolidation; Female; Humans; Learning; Magnetic Resonance Imaging - methods; Male; Memory; Orientation behavior; Photic Stimulation - methods; Retina; Somatosensory cortex; Training; Visual cortex; Visual Cortex - diagnostic imaging; Visual Cortex - physiology; Visual Perception - physiology; Visual tasks; Wakefulness - physiology; Young Adult; fMRI; learning; V1; perceptual decision making; awake reactivation
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.0884-18.2018

Brain activity patterns exhibited during task performance have been shown to spontaneously reemerge in the following restful awake state. Such “awake reactivation” has been observed across higher-order cortex for complex images or associations. However, it is still unclear whether the reactivation extends to primary sensory areas that encode simple stimulus features. To address this question, we trained human subjects from both sexes on a particular visual feature (Gabor orientation) and tested whether this feature will be reactivated immediately after training. We found robust reactivation in human V1 that lasted for at least 8 min after training offset. This effect was not present in higher retinotopic areas, such as V2, V3, V3A, or V4v. Further analyses suggested that the amount of awake reactivation was related to the amount of performance improvement on the visual task. These results demonstrate that awake reactivation extends beyond higher-order areas and also occurs in early sensory cortex. SIGNIFICANCE STATEMENT How do we acquire new memories and skills? New information is known to be consolidated during offline periods of rest. Recent studies suggest that a critical process during this period of consolidation is the spontaneous reactivation of previously experienced patterns of neural activity. However, research in humans has mostly examined such reactivation processes in higher-order cortex. Here we show that awake reactivation occurs even in the primary visual cortex V1 and that this reactivation is related to the amount of behavioral learning. These results pinpoint awake reactivation as a process that likely occurs across the entire human brain and could play an integral role in memory consolidation.