Tuberculosis case-contact research in endemic tropical settings: design, conduct, and relevance to other infectious diseases

Summary The study of the contacts of patients with tuberculosis has a long history. Where tuberculosis is endemic, regular recruitment of tuberculosis cases and their household contacts can be done for research and strategic intervention. This recruitment provides a platform whereby host, pathogen,...

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Published inThe Lancet infectious diseases Vol. 10; no. 10; pp. 723 - 732
Main Authors Hill, Philip C, Prof, Ota, Martin OC, MD
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 01.10.2010
Lancet Publishing Group
Elsevier Limited
Subjects
Bacterial diseases
Biological and medical sciences
Biomedical Research - ethics
Biomedical Research - methods
Contact Tracing - methods
Data management
Data processing
Endemic Diseases
Environmental factors
Family Health
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Medical sciences
Mycobacterium
Specimen Handling - methods
Tuberculosis
Tuberculosis - epidemiology
Tuberculosis - transmission
Tuberculosis and atypical mycobacterial infections
Infection
Bacteriosis
Tuberculosis
Mycobacterial infection
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Summary:Summary The study of the contacts of patients with tuberculosis has a long history. Where tuberculosis is endemic, regular recruitment of tuberculosis cases and their household contacts can be done for research and strategic intervention. This recruitment provides a platform whereby host, pathogen, and environmental factors related to tuberculosis can be investigated and new interventions can be assessed. We describe the types of study possible within a tuberculosis case-contact study platform and its essential components, including recruitment and follow-up of the patients with tuberculosis, their household contacts and community controls, assessments and sampling, and data management and processing. Sample handling and storage, local engagement, ethical challenges, and the strengths and weaknesses of study design are all important issues in case-contact research. A case-contact study platform is a powerful research tool to answer fundamental questions in tuberculosis and has relevance to the study of other major infectious diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(10)70164-X