Minimal stimulation using gonadotropin-releasing hormone (GnRH) antagonist and recombinant human follicle-stimulating hormone versus GnRH antagonist multiple-dose protocol in low responders undergoing in vitro fertilization/intracytoplasmic sperm injection

• Published in: Fertility and sterility Vol. 92; no. 6; pp. 2082 - 2084
• Main Authors: Kim, Chung-Hoon, M.D., Ph.D, Kim, So-Ra, M.D, Cheon, Yong-Pil, Ph.D, Kim, Sung-Hoon, M.D, Chae, Hee-Dong, M.D, Kang, Byung-Moon, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2009; Elsevier
• Subjects: Biological and medical sciences; Dose-Response Relationship, Drug; Female; Fertilization in Vitro; Follicle Stimulating Hormone - administration & dosage; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; Medical sciences; Obstetrics and Gynecology; Oocyte Retrieval; Ovulation Induction - methods; Pregnancy; Pregnancy Rate; Prospective Studies; Recombinant Proteins - administration & dosage; Sperm Injections, Intracytoplasmic; Multiple dose; In vitro fertilization embryo transfer; Human; Intracytoplasmic sperm injection; Gynecology; Gonadotropin RH; Assisted procreation; Stimulation; Antagonist; Obstetrics; Comparative study; Follicle stimulating hormone
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2009.06.005

This prospective randomized study was performed to investigate the effectiveness of minimal stimulation using recombinant human FSH (rhFSH) and GnRH antagonist compared with GnRH antagonist multiple-dose protocol (MDP) in low responders undergoing IVF/intracytoplasmic sperm injection. Our study demonstrated that minimal stimulation in natural cycles provides similar pregnancy rates to the GnRH antagonist MDP with fewer dose and days of rhFSH used and thus can be a cost-effective alternative as a last chance before oocyte donation in low responders.