The deubiquitinating enzyme USP11 regulates breast cancer progression by stabilizing PGAM5

• Published in: Breast cancer research : BCR Vol. 26; no. 1; pp. 135 - 13
• Main Authors: Zhang, Nannan, Wang, Quhui, Lu, Yunpeng, Wang, Feiran, He, Zhixian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.09.2024; BioMed Central; BMC
• Subjects: Animals; Antibodies; Apoptosis; Apoptosis - genetics; Bioinformatics; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell cycle; Cell death; Cell growth; Cell Line, Tumor; Cell Proliferation; Development and progression; Disease Progression; Enzymes; Female; Ferroptosis; Flow cytometry; Gene Expression Regulation, Neoplastic; Glutathione; Glycolytic enzymes; Health aspects; Humans; Lipid peroxidation; Lipids; Medical prognosis; Metastases; Mice; Mitochondrial Proteins; PGAM5; Phosphoglycerate mutase; Phosphoprotein Phosphatases - genetics; Phosphoprotein Phosphatases - metabolism; Physiological aspects; Plasmids; Proteasomes; Protein Stability; Proteins; Statistical analysis; Thiolester Hydrolases - genetics; Thiolester Hydrolases - metabolism; Ubiquitin-proteasome system; Ubiquitin-specific proteinase; Ubiquitination; USP11; China; Ferroptosis; Breast cancer; PGAM5; USP11

Breast cancer is common worldwide. Phosphoglycerate mutase 5 (PGAM5) belongs to the phosphoglycerate mutase family and plays an important role in many cancers. However, research on its role in breast cancer remains unclear. The present investigation highlights the significant expression of PGAM5 in...