Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte pr...
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| Published in | Frontiers in cell and developmental biology Vol. 9; p. 664168 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
28.05.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2296-634X 2296-634X |
| DOI | 10.3389/fcell.2021.664168 |
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| Abstract | Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury. |
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| AbstractList | Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury. Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury.Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury. |
| Author | Hu, Shi Chen, Hui Liu, Ren-Qin Tan, Xiao-Ning Wu, Ping Peng, Li-Hong Li, Yong-Min |
| AuthorAffiliation | 3 Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University , Xiangtan , China 2 The Affiliated Hospital of Hunan Academy of Chinese Medicine , Changsha , China 1 Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine , Changsha , China 5 School of Computer, Hunan University of Technology , Zhuzhou , China 4 Center for Bionic Sensing and Intelligence, Institute of Bio-medical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen , China |
| AuthorAffiliation_xml | – name: 1 Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine , Changsha , China – name: 2 The Affiliated Hospital of Hunan Academy of Chinese Medicine , Changsha , China – name: 4 Center for Bionic Sensing and Intelligence, Institute of Bio-medical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen , China – name: 3 Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University , Xiangtan , China – name: 5 School of Computer, Hunan University of Technology , Zhuzhou , China |
| Author_xml | – sequence: 1 givenname: Hui surname: Chen fullname: Chen, Hui – sequence: 2 givenname: Xiao-Ning surname: Tan fullname: Tan, Xiao-Ning – sequence: 3 givenname: Shi surname: Hu fullname: Hu, Shi – sequence: 4 givenname: Ren-Qin surname: Liu fullname: Liu, Ren-Qin – sequence: 5 givenname: Li-Hong surname: Peng fullname: Peng, Li-Hong – sequence: 6 givenname: Yong-Min surname: Li fullname: Li, Yong-Min – sequence: 7 givenname: Ping surname: Wu fullname: Wu, Ping |
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| Copyright | Copyright © 2021 Chen, Tan, Hu, Liu, Peng, Li and Wu. Copyright © 2021 Chen, Tan, Hu, Liu, Peng, Li and Wu. 2021 Chen, Tan, Hu, Liu, Peng, Li and Wu |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Tomokazu Tomo Fukuda, Iwate University, Japan This article was submitted to Cell Growth and Division, a section of the journal Frontiers in Cell and Developmental Biology These authors have contributed equally to this work Reviewed by: Hiroshi Tomita, Iwate University, Japan; Kyoung-ha So, Seoul National University, South Korea |
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| Title | Molecular Mechanisms of Chondrocyte Proliferation and Differentiation |
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