Molecular Mechanisms of Chondrocyte Proliferation and Differentiation

Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte pr...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 664168
Main Authors Chen, Hui, Tan, Xiao-Ning, Hu, Shi, Liu, Ren-Qin, Peng, Li-Hong, Li, Yong-Min, Wu, Ping
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 28.05.2021
Subjects
Cell and Developmental Biology
chondrocyte
FGF
growth factor
TGF-β
transcription factor
Wnt
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Summary:Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury.
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Edited by: Tomokazu Tomo Fukuda, Iwate University, Japan
This article was submitted to Cell Growth and Division, a section of the journal Frontiers in Cell and Developmental Biology
These authors have contributed equally to this work
Reviewed by: Hiroshi Tomita, Iwate University, Japan; Kyoung-ha So, Seoul National University, South Korea
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.664168