The relationships between clinical characteristics, alcohol and psychotropic exposure, and circadian gene expression in human postmortem samples of affective disorder and control subjects

• Published in: Psychiatry research Vol. 218; no. 3; pp. 359 - 362
• Main Authors: Gonzalez, Robert, Bernardo, Carmina, Cruz, Dianne, Walss-Bass, Consuelo, Thompson, Peter M.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 30.08.2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Alcohol Drinking - genetics; Autopsy; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - pathology; Bipolar disorders; Brain - pathology; Case-Control Studies; Circadian Clocks - genetics; Circadian genes; Circadian Rhythm - genetics; Depression; Depressive Disorder, Major - genetics; Depressive Disorder, Major - pathology; Female; Gene Expression; Gene Expression Profiling; Humans; Major depressive disorder; Male; Medical sciences; Miscellaneous; Mood disorders; Mood Disorders - genetics; Mood Disorders - pathology; Period Circadian Proteins - genetics; Postmortem Changes; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reference Values; Circadian genes; Bipolar disorder; Major depressive disorder; Human; Mood disorder; Psychotropic; Postmortem; Clinical form; Depression; Biological rhythm; Exposure; Circadian rhythm; Gene expression; Genetic determinism; Affective disorder; Alcoholic beverage; Gene; Genetics
• ISSN: 0165-1781; 1872-7123; 1872-7123
• DOI: 10.1016/j.psychres.2014.04.048

Circadian abnormalities may be related to mood disorders. Circadian gene expression was measured in postmortem brain tissue from individuals with affective disorders and controls. Relationships between circadian gene expression, clinical characteristics, and alcohol and psychotropic medication use were noted. Further study is warranted to characterize these relationships.