Determinants of brachial-ankle pulse wave velocity in a Japanese population: A cohort study

• Published in: Blood pressure Vol. 21; no. 6; pp. 338 - 344
• Main Authors: Mitani, Satoko, Fujita, Masatoshi, Shigeta, Masako, Kuriyama, Nagato, Ozaki, Etsuko, Yoshikawa, Aya, Matsui, Daisuke, Watanabe, Isao, Inoue, Kaoru, Watanabe, Yoshiyuki
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2012; Taylor & Francis
• Subjects: Adult; Aged; Ankle - blood supply; Ankle - physiopathology; Arterial Pressure; Asian Continental Ancestry Group; Atherosclerosis - diagnosis; augmentation index; Brachial Artery - physiopathology; Cohort Studies; Coronary Artery Disease - physiopathology; Female; framingham risk score; Humans; hypertension; Hypertension - physiopathology; Male; Middle Aged; pluse wave velocity; Pulse Wave Analysis - instrumentation; Pulse Wave Analysis - methods; Risk Factors; Vascular Stiffness - physiology
• ISSN: 0803-7051; 1651-1999
• DOI: 10.3109/08037051.2012.686176

Abstract Arterial stiffness is one of the biggest predictors of coronary heart disease (CHD). We evaluated whether brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) are correlated with risk factors of CHD. All of the 528 participants (270 males and 258 females) in this study were healthy workers aged from 36 to 69 (mean age: 47.9 ± 8.1 years). The Framingham Risk Score (FRS) showed a good correlation with baPWV (r = 0.53, p < 0.01), indicating that FRS is also applicable as an index of arterial stiffness in Japanese people. Blood pressures were well controlled in patients with medical treatment for hypertension; however, vessels remained relatively still stiff, whereas the AI was considerably low. Multivariate linear regression analysis showed that factors of such as FRS, body mass index, alcohol consumption and AI P75 were significantly correlated with baPWV.