Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial role in cellular mechanotransduction. Thus, infor...

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Published inFrontiers in pharmacology Vol. 12; p. 671809
Main Authors Kong, Qihang, Quan, Yue, Tian, Geer, Zhou, Junteng, Liu, Xiaojing
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 07.05.2021
Subjects
cellular mechanotransduction
mechanical stress
mechanoreceptors
nucleotides
Pharmacology
purinergic P2 receptors
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Summary:Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial role in cellular mechanotransduction. Thus, information on the specific mechanism of P2 receptor-mediated mechanotransduction would be valuable. In this review, we focus on purinergic P2 receptor signaling pathways and describe in detail the interaction of P2 receptors with other mechanosensitive molecules, including transient receptor potential channels, integrins, caveolae-associated proteins and hemichannels. In addition, we review the activation of purinergic P2 receptors and the role of various P2 receptors in the regulation of various pathophysiological processes induced by mechanical stimuli.
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Edited by: Francesco Caciagli, University of Studies G.d’Annunzio Chieti and Pescara, Italy
Sonja Buvinic, University of Chile, Chile
Talita Glaser, University of São Paulo, Brazil
Reviewed by: Luca Antonioli, University of Pisa, Italy
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.671809