Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an eff...

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Published inBiochip journal Vol. 16; no. 2; pp. 128 - 145
Main Authors Byun, Min Ji, Lim, Jaesung, Kim, Se-Na, Park, Dae-Hwan, Kim, Tae-Hyung, Park, Wooram, Park, Chun Gwon
Format Journal Article
LanguageEnglish
Published Seoul The Korean BioChip Society (KBCS) 01.06.2022
Springer Nature B.V
한국바이오칩학회
Subjects
Acids
Atherosclerosis
Biomedical Engineering and Bioengineering
Biotechnology
Brain research
Cancer therapies
Chemistry
Chemistry and Materials Science
Cystic fibrosis
Efficiency
Gene expression
Genomes
Immunogenicity
Infectious diseases
Kinases
Lipids
Melanoma
MicroRNAs
mRNA
mRNA vaccines
Nanoparticles
Nanotechnology
Ovarian cancer
Peptides
Platforms
Polymers
Prostate
Protein expression
Proteins
Review
Review Article
Ribonucleic acid
RNA
Severe acute respiratory syndrome coronavirus 2
siRNA
Toxicity
Tumor necrosis factor-TNF
생물공학
Nanoparticles
RNA delivery
Gene therapy
Nanomedicine
Biomaterials
Online AccessGet full text
ISSN1976-0280
2092-7843
DOI10.1007/s13206-022-00052-5

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Abstract RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptide-derived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.
AbstractList RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptidederived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives. KCI Citation Count: 0
RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptide-derived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptide-derived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.
RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptide-derived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.
Author Lim, Jaesung
Park, Chun Gwon
Byun, Min Ji
Kim, Se-Na
Kim, Tae-Hyung
Park, Dae-Hwan
Park, Wooram
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  organization: Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Department of Intelligent Precision Healthcare Convergence, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Center for Neuroscience Imaging Research, Institute for Basic Science (IBS)
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Issue 2
Keywords Nanoparticles
RNA delivery
Gene therapy
Nanomedicine
Biomaterials
Language English
License The Korean BioChip Society 2022.
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Snippet RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction...
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StartPage 128
SubjectTerms Acids
Atherosclerosis
Biomedical Engineering and Bioengineering
Biotechnology
Brain research
Cancer therapies
Chemistry
Chemistry and Materials Science
Cystic fibrosis
Efficiency
Gene expression
Genomes
Immunogenicity
Infectious diseases
Kinases
Lipids
Melanoma
MicroRNAs
mRNA
mRNA vaccines
Nanoparticles
Nanotechnology
Ovarian cancer
Peptides
Platforms
Polymers
Prostate
Protein expression
Proteins
Review
Review Article
Ribonucleic acid
RNA
Severe acute respiratory syndrome coronavirus 2
siRNA
Toxicity
Tumor necrosis factor-TNF
생물공학
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Title Advances in Nanoparticles for Effective Delivery of RNA Therapeutics
URI https://link.springer.com/article/10.1007/s13206-022-00052-5
https://www.ncbi.nlm.nih.gov/pubmed/35261724
https://www.proquest.com/docview/2919610710
https://www.proquest.com/docview/2637585635
https://pubmed.ncbi.nlm.nih.gov/PMC8891745
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002848484
Volume 16
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ispartofPNX BioChip Journal, 2022, 16(2), , pp.128-145
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