Pathogenesis of Acute Aortic Dissection: A Finite Element Stress Analysis

• Published in: The Annals of thoracic surgery Vol. 91; no. 2; pp. 458 - 463
• Main Authors: Nathan, Derek P., MD, Xu, Chun, PhD, Gorman, Joseph H., MD, Fairman, Ron M., MD, Bavaria, Joseph E., MD, Gorman, Robert C., MD, Chandran, Krishnan B., PhD, Jackson, Benjamin M., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2011; Elsevier
• Subjects: Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Aneurysm, Dissecting - diagnostic imaging; Aneurysm, Dissecting - physiopathology; Angiography - methods; Aorta, Thoracic - physiopathology; Aortic Aneurysm, Thoracic - diagnostic imaging; Aortic Aneurysm, Thoracic - physiopathology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiothoracic Surgery; Computer Simulation; Diseases of the aorta; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Finite Element Analysis; Humans; Male; Medical sciences; Middle Aged; Models, Cardiovascular; Pneumology; Stress, Mechanical; Surgery; 26; Pathogenesis; Acute; Cardiovascular disease; Stress; Arterial disease; Vascular disease; Analysis; Anesthesia; Aortic dissection; Circulatory system; Cardiology; Aortic disease; Finite element
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/j.athoracsur.2010.10.042

Background Type A and type B aortic dissections typically result from intimal tears above the sinotubular junction and distal to the left subclavian artery (LSA) ostium, respectively. We hypothesized that this pathology results from elevated pressure-induced regional wall stress. Methods We identified 47 individuals with normal thoracic aortas by electrocardiogram-gated computed tomography angiography. The thoracic aorta was segmented, reconstructed, and triangulated to create a geometric mesh. Finite element analysis using a systolic pressure load of 120 mm Hg was performed to predict regional thoracic aortic wall stress. Results There were local maxima of wall stress above the sinotubular junction in the ascending aorta and distal to the ostia of the supraaortic vessels, including the LSA, in the aortic arch. No local maximum of wall stress was found in the descending thoracic aorta. Comparison of the mean peak wall stress above the sinotubular junction (0.43 ± 0.07 MPa), distal to the LSA (0.21 ± 0.07 MPa), and in the descending thoracic aorta (0.06 ± 0.01 MPa) showed a significant effect for wall stress by aortic region ( p < 0.001). Conclusions In the normal thoracic aorta, there are peaks in wall stress above the sinotubular junction and distal to the LSA ostium. This stress distribution may contribute to the pathogenesis of aortic dissections, given their colocalization. Future investigations to determine the utility of image-derived biomechanical calculations in predicting aortic dissection are warranted, and therapies designed to reduce the pressure load-induced wall stress in the thoracic aorta are rational.