Severe hypercalcemia: A rare and unusual presentation of acute lymphoblastic leukemia

Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological...

Full description

Saved in:
Bibliographic Details
Published inJournal of cancer research and therapeutics Vol. 14; no. 12; pp. 1244 - 1246
Main Authors Dhivyasree, Swaminathan, Dhivyalakshmi, Jeevarathnam, Sankaranarayanan, Shuba, Scott, Julius
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.12.2018
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Subjects
Acids
Acute lymphocytic leukemia
Blood
Bone marrow
Brain cancer
Chemotherapy
Children & youth
Complications and side effects
Hydration
Hypercalcemia
Leukemia
Lymphocytic leukemia
Metabolism
Pain
Pediatric research
Radiology
Risk factors
Tumor necrosis factor-TNF
Vitamin D
hypercalcemia
Acute lymphoblastic leukemia
children
osteolytic lesion
Online AccessGet full text

Cover

More Information
Summary:Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological evidence of osteolytic lesions. Malignancies are the most common parathyroid hormone-independent cause of hypercalcemia. Severe hypercalcemia is a life-threatening emergency that should be addressed immediately. Effective treatment includes intense hydration, frusemide, calcitonin, and bisphosphonate in addition to the treatment of underlying cause.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.187240