Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

• Published in: Journal of Pharmacological Sciences Vol. 122; no. 1; pp. 55 - 58
• Main Authors: Kuroda, Wakana, Kitamura, Yoshiaki, Mizuguchi, Hiroyuki, Miyamoto, Yuko, Kalubi, Bukasa, Fukui, Hiroyuki, Takeda, Noriaki
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 2013; The Japanese Pharmacological Society; Elsevier
• Subjects: Animals; antihistamine; Chlorpheniramine - administration & dosage; Chromones - administration & dosage; cysteinyl leukotoriene receptor antagonist; Drug Therapy, Combination; Histamine Antagonists - administration & dosage; histamine H1-receptor; Hypersensitivity - drug therapy; Hypersensitivity - etiology; Hypersensitivity - metabolism; Leukotriene Antagonists - administration & dosage; Male; Nasal Mucosa - metabolism; Rats; Receptors, Histamine H1 - genetics; RNA, Messenger - metabolism; Toluene 2,4-Diisocyanate - adverse effects; antihistamine; cysteinyl leukotoriene receptor antagonist; histamine H1–receptor
• ISSN: 1347-8613; 1347-8648
• DOI: 10.1254/jphs.12250SC

An attempt was made to clarify the additive suppressive effects of pranlukast, a cysteinyl leukotriene–receptor (LTR) antagonist, in combination with chlorpheniramine, an antihistamine, on the up-regulation of histamine H1–receptor (H1R) mRNA in toluene 2,4-diisocyanate (TDI)-sensitized rats. Although pre-treatment with pranlukast partially, but significantly, suppressed TDI-induced up-regulation of H1R mRNA and nasal symptoms, pre-treatment with the combination of pranlukast and chlorpheniramine significantly suppressed them in a manner greater than either drug alone. These findings suggest that the additive therapeutic effect of the combination of LTR antagonist and antihistamine is due to their additive suppression of H1R up-regulation.